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The supernatants were collected, and the pellets were resuspended in 0.2 N NaOH for protein determination

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They do not shut it down completely, which would compromise immune function, but rather dial it back toward normal levels

Starting at lower doses and escalating gradually gives the body time to adapt without the full intensity of adjustment happening all at once

These studies are mechanistically aligned with the VEGFR2/eNOS in vitro findings but rely on the same originating laboratory and rodent model system, and independent replication outside that network is sparse

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